The hsa‐miR‐181a‐5p inhibits Wnt/β‐catenin and Pleomorphic Adenoma Gene 1 (PLAG1) pathways, enhancing the sensitivity of colorectal cancer cells to 5‐FU (Li et al. 2023; Shi et al. 2018). This evidence concerns the gene PLAG1 and colorectal cancer.