Fusobacterium nucleatum, a Gram-negative anaerobic bacterium, has been found to enhance GLUT1 aggregation in the plasma membrane and glycolysis via activation of the GalNAc-autophagy-TBC1D5 signaling pathway, leading to extracellular lactate accumulation and the formation of M2-like tumor-associated macrophages (TAMs) (Figure 2). Here, SLC2A1 is linked to neoplasm.