Conversely, elevated levels of HIF-1α can impact the efficacy of tumor therapy by modulating downstream and upstream molecular signaling pathways and influencing the expression of hypoxia-related genes involved in angiogenesis, erythropoiesis, glycolysis, cell adhesion, cell proliferation, and apoptosis (21), meanwhile, causing inadequate arterial blood supply, reduced vascular density, impaired vascular tissue transport efficiency, alterations in red blood cell flow, functional shunting, and imbalance of oxygen supply and demand (22). This evidence concerns the gene HIF1A and neoplasm.