HIF1A and neoplasm: In addition, the MK value of the parameter reflecting the complexity of tumor tissue was also higher in the high HIF-1α expression than that in the low expression groups, which was related to the fact that the expression of HIF-1α could regulate the proliferation and epithelial mesenchymal transition of tumor cells, resulting in the exuberant proliferation of tumor local cells, the increase of epithelial stromal transition and the complexity of tumor local structure (15, 16).