TJP1 and hypertriglyceridemia: It has been postulated that hypertriglyceridemia and high plasma LPS associated with HFD may be due to decreased expression of intestinal epithelial proteins such as Occludin and ZO-1 secondary to increased intestinal permeability (Wang et al., 2021; Dembek et al., 2017; Xu et al., 2007).