A recent study revealed that LPS increases N6-methyladenosine (m6A) methylation of GNAS mRNA, upregulating protein expression and activating STAT3 and IL-6 production (Zhang et al., 2020), thus outlining the GNAS-LPS-STAT3-IL-6 axis in HCC tumorigenesis. The gene discussed is IL6; the disease is hepatocellular carcinoma.