A recent study revealed that LPS increases N6-methyladenosine (m6A) methylation of GNAS mRNA, upregulating protein expression and activating STAT3 and IL-6 production (Zhang et al., 2020), thus outlining the GNAS-LPS-STAT3-IL-6 axis in HCC tumorigenesis. Here, GNAS is linked to hepatocellular carcinoma.