ALPI and cancer: Butyrate also acts as a differentiation-inducing agent in cancer cell lines, accompanied by increased levels of intestinal alkaline phosphatase (Alpi) and cluster 1 antigen (Hay et al., 1991; Tsukamoto et al., 1991; Ellerhorst et al., 1999; Gillenwater et al., 2000; Perego et al., 2018; Tylichova et al., 2018).