FZD2 and cancer: Figure 8C demonstrates a strong positive association between FZD2 and MATH in ESCA, STES, HNSC, LIHC, and BLCA, whereas negative correlations were observed in cancers such as GBMLGG, LGG, COAD, and BRCA. A radar plot showed significant positive correlations between FZD2 and TMB in ACC, BLCA, COAD, LGG, MESO, and THYM, while negative correlations were observed in BRCA, CESC, ESCA, HNSC, LIHC, and PRAD (Figure 8D). Additionally, FZD2 expression was significantly associated with MSI in 16 tumor types (Figure 8E).