GEPIA analysis corroborated these findings, showing significant elevation of FZD2 in tumor tissues compared to normal tissues in multiple cancer types, including BLCA, BRCA, CHOL, DLBC, ESCA, GBM, HNSC, OV, PAAD, SKCM, STAD, and UCS (P < 0.05) (Figures 2D,E). Here, FZD2 is linked to cancer.