PTHLH and neoplasm: Therefore, we speculate that TP may interact with the exogenous protein—PTHrP, blocking the binding of PTHrP to PTH1R on the surface of osteoblasts, inhibiting the excessive secretion of RANKL by osteoblasts in the tumor microenvironment, and indirectly inhibiting osteoclastogenesis, which is one of the effects of TP in the inhibition of bone metastasis (Figure 7).