Ursodeoxycholic acid (UDCA) has been shown to regulate the protein kinase B/mammalian target of rapamycin/sterol regulatory element-binding protein-1 (AKT/mTOR/SREBP-1) signaling pathway, reducing lipid accumulation in MASLD cell models induced by oleic acid (Chen et al., 2018). The gene discussed is AKT1; the disease is metabolic dysfunction-associated steatotic liver disease.