The CON/CUMS pair showed enrichment in pathways related to Aldosterone synthesis and secretion, Arachidonic acid metabolism, Cortisol synthesis and secretion, Cushing syndrome, parathyroid hormone synthesis, secretion, and action, and Vascular smooth muscle contraction (Supplementary Table 6). The gene discussed is PTH; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.