For instance, Hyperoside significantly mitigates depression-like behaviors in chronic stress-induced mice by inhibiting the NLRP1 inflammasome and modulating the CXCL1/CXCR2/BDNF signaling pathway, leading to improved anhedonia and reduced immobility time (Song et al., 2022). This evidence concerns the gene CXCR2 and major depressive disorder.