TNF and hypertensive disorder: During the inflammatory process induced by different risk factors as hypertension, oxidized low-density lipoprotein (oxLDL) and diabetes, there is an increase in the production of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) that generate the endothelial proinflammatory phenotype characterized by an increase in E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression (5).