Circulating LECT2 correlates with the severity of obesity and insulin resistance (Lan et al., 2014)Increased plasma LECT2 levels in patients with MASLD and metabolic syndrome (Yoo et al., 2017)Increased circulating LECT2 in T2DM patients and negative correlation with HDL cholesterol in diabetic and obese subjects (Zhang et al., 2018). The gene discussed is LECT2; the disease is obesity due to melanocortin 4 receptor deficiency.