SNPs in SHBG gene associated with increased risk of T2DM (Ding et al., 2009)Lower plasma SHBG levels in MASLD patients and associated with high-grade MASLD in patients with T2DM (Shin et al., 2011)Lower plasma SHBG levels in obese individuals (Cooper et al., 2015). The gene discussed is SHBG; the disease is type 2 diabetes mellitus.