Plasma ANGPTL8 levels are also increased in individuals with T1DM (Espes et al., 2014), T2DM (Espes et al., 2014; Fu et al., 2014; Hu et al., 2014) and obesity (Fu et al., 2014), and positively correlate with hepatic steatosis in MASLD patients (von Loeffelholz et al., 2017). The gene discussed is ANGPTL8; the disease is obesity due to melanocortin 4 receptor deficiency.