GDF15 treatment decreases food intake and body weight (Hale and Véniant, 2021)GDF15-deficient mice show increased food intake and body weight, and impaired glucose tolerance (Wang et al., 2021)GDF15-overexpressing mice have diminished food intake and body weight, and also improved insulin sensitivity (Wang et al., 2021). This evidence concerns the gene INS and Impaired glucose tolerance.