Circulating LECT2 correlates with the severity of obesity and insulin resistance (Lan et al., 2014)Increased plasma LECT2 levels in patients with MASLD and metabolic syndrome (Yoo et al., 2017)Increased circulating LECT2 in T2DM patients and negative correlation with HDL cholesterol in diabetic and obese subjects (Zhang et al., 2018). This evidence concerns the gene LECT2 and metabolic dysfunction-associated steatotic liver disease.