FGF21 and type 2 diabetes mellitus: Also, circulating FGF21 is increased in overweight/obese individuals (Zhang et al., 2008; Ďurovcová et al., 2010), and in patients with MASLD (Dushay et al., 2010) and T2DM (Cheng et al., 2011), and in women with gestational diabetes (Tan et al., 2013).