In humans, circulating ANGPTL4 is increased in T2DM patients (Babapoor-Farrokhran et al., 2015; McCulloch et al., 2020) and in obese individuals (Schinzari et al., 2021) and to decrease, together with body weight and fat mass, after bariatric surgery (Bini et al., 2022). The gene discussed is ANGPTL4; the disease is type 2 diabetes mellitus.