CREB1 and Alzheimer disease: These findings align with previous studies showing that CREB signaling is reduced in neurodegenerative disease models such as AD and Parkinson’s disease and that increasing CREB phosphorylation can ameliorate these deficits (Pugazhenthi et al., 2011; Xu et al., 2022; Kim et al., 2020; Zhao et al., 2021).