Clinical studies and a meta-analysis of genome-wide association studies (GWAS) have demonstrated the strong association of apolipoprotein E (ApoE) with cognitive decline and the accumulation of amyloid-beta 42 (Aβ42) in patients with AD (Corder et al., 1993; Bellenguez et al., 2022; Im and Choi, 2024). The gene discussed is APOE; the disease is Alzheimer disease.