For the genetic variants exhibiting pleiotropy (Table S6), we excluded rs2495495 and rs557435 in the analysis of PCSK9‐mediated LDL and EC (Figure S5A), excluded rs1159114 and rs11591147 in the analysis of PCSK9‐mediated LDL and colon cancer (Figure S5B,C), and excluded rs10788994, rs10788994, and rs11591147 in the analysis of PCSK9‐mediated LDL and pancreatic head cancer (Figure S5D). This evidence concerns the gene PCSK9 and malignant colon neoplasm.