LDL mediated by NPC1L1 showed a positive correlation with EC (OR = 6.50, 95% CI: 1.34–31.42, p = 0.02), GC (OR = 20.17, 95% CI: 7.23–56.30, p < 0.01), CRC (OR = 2.64, 95% CI: 1.64–4.26, p < 0.01), and liver cancer (OR = 9.25, 95% CI: 2.11–40.51, p < 0.01). This evidence concerns the gene NPC1L1 and colorectal carcinoma.