NPC1L1‐mediated LDL was positively associated with GC (OR = 15.54, 95% CI: 5.96–40.56, p < 0.01) and CRC (OR = 2.37, 95% CI: 1.60–3.53, p < 0.01) (Figure S3). Here, NPC1L1 is linked to colorectal carcinoma.