In the meta‐analysis, HMGCR‐mediated LDL was negatively associated with colon cancer (OR = 0.62, 95% CI: 0.49–0.78, p < 0.01) and hepatocellular carcinoma (OR = 0.06, 95% CI: 0.00–0.81, p = 0.03). Here, HMGCR is linked to hepatocellular carcinoma.