Jiang et al. showed that apolipoprotein A-I binding protein (AIBP) regulates cholesterol metabolism and inhibits hypoxia-induced activation of HIF-1α, thereby reducing angiogenesis in IH, suggesting AIBP as a potential therapeutic target for IH (Jiang et al., 2024). The gene discussed is HIF1A; the disease is isolated hemihyperplasia.