HIF1A and infection: The latent nuclear antigen (LANA) encoded by ORF73, which is expressed during the latent phase of infection, forms a complex with HIF-1α and recruits chromatin remodeling enzyme KAP1 to the RTA promoter region, further regulating the initiation of lytic replication (Cai Q. et al., 2006; Cai et al., 2013).