NOTCH1 and fetal growth restriction: Mechanistic insights from Li and colleagues identified enhanced activation of the Notch1 signaling pathway in IUGR-affected human umbilical vein endothelial cells (HUVECs), with subsequent activation of protein kinase B (Akt) and extracellular signal-regulated protein kinases 1/2 (ERK1/2) (Li M. et al., 2022).