Overexpression of HAT p300 in human embryonic kidney 293T (HEK293T) cells significantly enhanced the global lactylation levels of histones, whereas knockout of the EP300 gene, which encodes p300, reduced global histone lactylation and H3K18la levels in human colon cancer HCT116 cells and HEK293T cells [41]. This evidence concerns the gene EP300 and malignant colon neoplasm.