They found that H3K18la increased its binding to the Rela (p65) and NFκB1 (p50) promoters, leading to the activation of the NFκB signaling pathway and promoting the generation of age‐related secretory phenotype (SASP) components IL‐6 and IL‐8, further influencing brain aging and AD phenotypes [145]. This evidence concerns the gene RELA and Alzheimer disease.