Studies have shown that lactate derived from colorectal tumors directly mediates the lactylation of the methyltransferase‐like METTL3 zinc finger domain, which enhances the binding and catalytic activity of METTL3 on Janus kinase 1 (JAK1) mRNA, facilitating m6A modification [64, 183]. This evidence concerns the gene JAK1 and colorectal neoplasm.