CASP1 and Cognitive impairment: Moreover, systemic inflammasome activation (Rui et al., 2021) triggers a self-sustaining loop that leads the healthy brain to the Alzheimer’s manifestation through a cognitive impairment and finally to the Alzheimer’s manifestation, as recently confirmed by the role of the aberrant expression of Nucleotide-binding oligomerization domain (NOD), Leucine rich Repeat and Pyrin domain containing (NLRP) inflammasome activated caspase-1 (Beder et al., 2024).