For example, in a recent study by Lee et al. (2022), while certain features such as Aβ deposits aligned with histopathological findings, the expression levels of AD-related genes Microtubule-Associated Protein Tau (MAPT) and Amyloid Precursor Protein (APP) were similar when comparing iPSCs derived from normal and familial AD patients. This evidence concerns the gene MAPT and Alzheimer disease.