CXCR2-dependent regulation modulates the formation, angiogenesis, and metastasis of pancreatic cancer, with CXCR2 also promoting immune evasion and cancer development through autocrine effects, while recent experiments show that cell-autonomous CXCL5 maintains tolerance loops and stromal inflammation by inducing TNF derived from neutrophils in cancer cells (101, 102). Here, CXCR2 is linked to familial pancreatic carcinoma.