In addition, the transcriptomic variations in all the lung lobes revealed upregulated inflammatory pathways in all the lobes, for example, TNF-α signaling via NF-κb, IL6 JAK STAT3 signaling, the IFN-γ response, the reactive oxygen species pathway, and allograft rejection, which play proinflammatory roles in recipients with GVHD (14, 25–27). This evidence concerns the gene TNF and graft versus host disease.