(13) found that malignant ascites-derived ovarian cancer exosomes bind to TLR2 and TLR4 on THP-1 cells, thus eliciting the secretion of pro-inflammatory cytokines like IL-1β, TNF-α, IL-and 6, IL-8 by activation of NF-κB- and STAT3-dependent signaling. The gene discussed is STAT3; the disease is ovarian cancer.