DGKK and hypothyroidism: Therefore, we hypothesized that the downregulation of DGKK and S10A8 is involved in the development of hypothyroidism in the first half of pregnancy, which may (1) reduce Diacylglycerol (DAG) phosphorylation and inhibit phosphatidic acid production by the protein kinase C pathway by downregulation of DGKK (46), which reduces PI in the phosphatidylinositol signaling pathway (45) and in turn affects inositol-dependent thyroid stimulating hormone (TSH) signaling (47), resulting in altered TSH synthesis and secretion and leading to hypothyroidism (48) (2).