IGHE and common variable immunodeficiency: As shown in Table 3, all immunoglobulin classes (IgG and subclasses, IgA, IgM, and IgE) were, on average, lower in the GLILD+ group at both time points, with IgA (p = 0.024) and IgG4 (p = 0.030) being significantly inferior in the GLILD+ group at CVID diagnosis.