Immunophenotyping revealed an absolute leukocyte and lymphocyte and relative CD3+ PAN-T cell increase; an absolute CD4+ and CD8+ T-cell expansion skewed towards a prevalence of the effector subsets in face of a relative naïve and regulatory T-cell (T-reg) diminishment; specular CD19+ naïve, transitional, and CD21low B subsets predominance on memory; and switched memory B lymphocytes in the GLILD+ group compared to the controls. Here, CD4 is linked to polyarteritis nodosa.