OZO: ozonated olive oil; PV: peroxide value; PI: plaque index; Gi: gingival index; DNBS: 2, 4-dinitrobenzene sulfonic acid; SOD: superoxide dismutase; GSH-Px: glutathione peroxidase; ROS: reactive oxygen species; BXO: balanitis xerotica obliterans. The gene discussed is SOD1; the disease is penile disorder.