These deficiencies include X-linked agammaglobulinemia (XLA), also known as Bruton's tyrosine kinase (BTK) deficiency; certain types of autosomal-dominant immunodeficiencies (such as Hoffman syndrome, PU1 deficiency, and E47 transcription factor deficiency), and several autosomal-recessive immunodeficiencies. This evidence concerns the gene BTK and hyperinsulinemic hypoglycemia, familial, 4.