It was found that MLT, SKT, and IPA were down-regulated in all cancer groups (except IND replaces IPA in GC group), acetic acid and butyric acid down-regulated, while heptylic acid and valeric acid up-regulated in CC groups, isovaleric acid up-regulated in EC, and RCC and cortisol up-regulated only in EC group. The gene discussed is KIAA1217; the disease is cancer.