PDGFRA and gastrointestinal stromal tumor: Compared to tumors such as gastric cancer and colorectal cancer, which involve multiple gene and pathway mutations, the mutation targets of GIST are relatively singular, mainly focusing on mutations in tyrosine protein kinase (c-KIT) (80%) and platelet-derived growth factor receptor alpha (PDGFRA) (10%), with the rest classified as wild-type [2].