To explorethis, we intraperitoneally (i.p.)injected PICS and sepsis model mice with anti-CD115,anti-B220, and anti-CD25 antibodies to deplete monocytes, B cells, and CD4 Tregs,respectively, and then observed whether there was a change in the number of MKs ( Figure 4A). The gene discussed is CD4; the disease is Sepsis.