MAX and chronic myelogenous leukemia, BCR-ABL1 positive: Whether MYC/MAX binding around TESs allows genes to engage in DoG transcription or direct TSS contacts might be further influenced by heterodimers comprised of MAX and members of the MXD family, which negate the positive transcriptional activity of MYC.[1, 4] Using available ChIPseq results from ENCODE for these factors that were reported for human HepG2 HCC cells and K562 chronic myelogenous leukemia cells, we found evidence for their binding to regions around both TSSs and TESs (Figure 6J).