MYC and hepatocellular carcinoma: Another example of target gene binding and gene expression changes in response to pathologic levels of MYC occurred in undifferentiated hepatocellular carcinomas (HCCs) induced by the conditional over‐expression of a human MYC transgene.[5b,c] Despite its exceedingly low level expression in livers, MYC binding was nonetheless again detected at high‐affinity 5′‐ and 3′‐ends, whereas its binding to lower‐affinity sites was noted only in response to its over‐expression (Figure 3G–I).