In neurological disorders like multiple sclerosis, parkinson’s disease (PD), HIV-1-associated dementia (HAD), and alzheimer’s disease, activated astrocytes secrete pro-inflammatory mediators (various cytokines and chemokines) by activating NF-κB and STAT3 pathways, causing cell injury in the brain [9, 10]. Here, NFKB1 is linked to Parkinson disease.