Transforming growth factor-β (TGFβ) has been observed to promote this pro-tumor phenotype (N2 TANs); however, IFNβ or the inhibition of TGFβ signaling promotes anti-tumor phenotype of TANs (N1 TANs).59 Lastly, there was a larger population of immature B cells present in H2-PD samples, which may play a suppressive or pro-inflammatory role in the glioma microenvironment; however, little is known about the role of immature B cells and the tumor glioma microenvironment. Here, IFNB1 is linked to central nervous system cancer.