A high proportion of individuals requiring corrective scoliosis surgery was identified among those with AMC associated with the following genes, all associated with neuromuscular diseases: COL6A1 (100%, 2/2), TOR1A (100%, 2/2), RYR1 (100%, 3/3), CHRNG (80%, 4/5), PIEZO2 (80%, 4/5), TTN (67%, 6/9), ZC4H2 (40%, 2/5), and DYNC1H1 (40%, 2/5) (Figure 2 and Tables 1, 2, 3). The gene discussed is ZC4H2; the disease is scoliosis.