Constitutive knock‐in mice with the P1195L mutation in the insulin receptor (IR‐KI mice) and those with a mutated amyloid precursor protein (AppNL‐G‐F mice: APP‐KI mice) were crossbred to obtain the resultant mice (APP/IR‐dKI mice) as AD models with insulin resistance for behavioral analysis. This evidence concerns the gene INSR and Alzheimer disease.