GLP1R and type 2 diabetes mellitus: Positive control analysis demonstrated that genetic instruments for the GLP1R gene were significantly associated with a reduced risk of T2DM (odds ratio [OR] = 0.90, 95% confidence interval [CI] = 0.86–0.96, p = 0.0004) and BMI (OR = 0.94, 95% CI = 0.92–0.96, p = 9.78E-08), validating their use as proxies for GLP-1RAs exposure (Table 2).