Mimicking Ewing sarcoma in mice has been challenging [39], however, a recent mouse model showed that while EWSR1::FLI1 may be sufficient for tumorigenesis, subsequent YAP1 activation induced by IGF1 signalling may be required for the activation of TEAD driven transcription and metastatic progression [10]. This evidence concerns the gene YAP1 and Ewing sarcoma.