In untreated clinical samples, driver mutations likewise to TP53 and RB1 were identified in Mendelian cancer driver genes BRCA2, BAP1, RET, MUTYH, ATM, PTEN, WRN and RECQL4 and cancer susceptibility genes ATRX, FANCA, NUMA1 and MDC1 [48]. This evidence concerns the gene RB1 and cancer.