In untreated clinical samples, driver mutations likewise to TP53 and RB1 were identified in Mendelian cancer driver genes BRCA2, BAP1, RET, MUTYH, ATM, PTEN, WRN and RECQL4 and cancer susceptibility genes ATRX, FANCA, NUMA1 and MDC1 [48]. Here, MDC1 is linked to cancer.