There is DNA hypomethylation at enhancer regions regulated by EWSR1::FLI1 [32] but differential DNA methylation between tumours suggest a continuous disease spectrum reflecting EWSR1::FLI1 regulatory signature strength, a continuum between mesenchymal and stem cell signatures potentially emulating the regulatory cell state from which the tumour originally derived [32]. The gene discussed is EWSR1; the disease is neoplasm.