IL1B and familial Mediterranean fever: Familial Mediterranean fever (FMF), tumor-necrosis factor receptor-associated periodic syndrome (TRAPS) and mevalonate-kinase deficiency (MKD), also known as hyperimmunoglobulin-D syndrome (HIDS), are a group of rare monogenic autoinflammatory diseases (AID) driven by the pro-inflammatory cytokine interleukin (IL)-1 [1].