DDB2 and xeroderma pigmentosum: In nucleotide excision repair (NER), which resolves bulky lesions like those caused by UV irradiation, CHD1L contributes to global genome NER (GG-NER) due to its association with xeroderma pigmentosum linked genes XPC and XPE, which coordinate repair of UV induced DNA damage through the DNA damage recognition complex (DDB2) [106].