In addition, activation of the PI3 K/Akt pathway can inhibit apoptosis of myocardial cells, but under the state of insulin resistance, the PI3 K/Akt pathway is inhibited, resulting in a decrease in anti-apoptotic ability and an increased risk of apoptosis in myocardial cells, leading to injury to the coronary disease heart cells and a reduction in myocardial cells [32, 33]; activation of the PI3 K/Akt pathway can also promote cell proliferation and migration, participating in the repair and regeneration process of myocardial tissue[34, 35]. This evidence concerns the gene AKT1 and coronary artery disorder.