Recent studies showed the significance of inflammatory biomarkers, including C-reactive protein (CRP), and interleukins (IL) (IL-1β, IL-6, IL-8, and IL-10), and tumor necrosis factor-alpha (TNF-α), are associated with PSCI26–28 The present study aimed to investigate the association between PSCI, gut microbiota, and inflammatory markers in patients with ischemic stroke. This evidence concerns the gene CRP and ischemic stroke.