Recent studies showed the significance of inflammatory biomarkers, including C-reactive protein (CRP), and interleukins (IL) (IL-1β, IL-6, IL-8, and IL-10), and tumor necrosis factor-alpha (TNF-α), are associated with PSCI26–28 The present study aimed to investigate the association between PSCI, gut microbiota, and inflammatory markers in patients with ischemic stroke. The gene discussed is TNF; the disease is ischemic stroke.