Decrease in hCTNNB1, indicative of tumor burden driven by mutant-CTNNB1, was enhanced in the LNP-CTNNB1 + α-PD1 compared to LNP-CTNNB1 + IgG treated mice (p = 0.0395) suggesting an augmented response to LNP-CTNNB1 with α-PD1 (Fig. 7i). Here, CTNNB1 is linked to neoplasm.