CTNNB1 and neoplasm: Additionally, the 0.3, 0.1, and 0.03 mg/kg LNP-CTNNB1 dosages resulted in partial responses, with remnant microscopic tumor foci observed in 0.3 and 0.1 mg/kg treated animals (Supplementary Fig. 2e) and macroscopic tumor nodules present in animals treated with 0.03 mg/kg (Supplementary Fig. 2b, e).