Similarly, in the β-M model, following treatment cessation, mice were moribund by ~16.5-weeks post-LNP-CTNNB1 treatment, with gross tumor burden becoming equivalent to the tumor burden observed in LNP-CTRL treated mice at ~7.5 weeks, which is a lethal timepoint in β-M model (Supplementary Fig. 5e, f). This evidence concerns the gene CTNNB1 and neoplasm.