CTNNB1 and neoplasm: We administered once weekly I.V. injections at 3, 1, 0.3, 0.1, and 0.03 mg/kg dosages over 6 weeks of LNP-CTNNB1 starting at 5-weeks post-HDTVi, which we previously determined as a timepoint when microscopic tumor foci are already established28 (Supplementary Fig. 2a).