CTNNB1 and neoplasm: β-Catenin suppression by LNP-CTNNB1 in the Nrf2-hMet (N-M) model at 8-weeks post-HDTVi, a timepoint with known microscopic tumor burden32, led to a decrease in liver weight and LW/BW and in macroscopic disease (Supplementary Fig. 4a–d), although there was persistence of some microscopic nodules, which depicted inferiority in response when compared to mutant-β-catenin-driven tumors (Supplementary Fig. 4e–g).