CTNNB1 and neoplasm: In the β-N model, following treatment cessation, mice were moribund by ~22.5-weeks post-LNP-CTNNB1 treatment, with gross tumor burden becoming equivalent to the tumor burden observed in LNP-CTRL treated mice at ~10.5 weeks, which is a lethal timepoint in β-N model (Supplementary Fig. 5a, b).