APC and neoplasm: Cell cycle phase-specific gene expression analysis on hepatocyte clusters importantly demonstrated that tumor cells (both Zone 3 CTNNB1 WT & MUT [GS+] and Zone 1/2 CTNNB1 MUT [GS+] hepatocytes) were the most proliferative, while reprogrammed hepatocytes and Zone 1 CTNNB1 WT (GS−) hepatocytes were the least proliferative with proportionally fewer cells in S and G2M phases of the cell cycle (Fig. 3c).