While there was no significant difference in gross tumor burden (Supplementary Fig. 7b), a single dose of LNP-CTNNB1 significantly decreased liver weight and LW/BW (Supplementary Fig. 7c–e), decreased intra-tumoral GS expression but retained V5-tag expression (Supplementary Fig. 7f, g). This evidence concerns the gene CTNNB1 and neoplasm.