Similarly, Tat-LNP X was able to induce productive infection in primary CD4+ T cells infected with an HIV reporter virus (pMorpheus-V535; p = 0.0025) similar to levels seen after T cell activation with the mitogens phorbol 12-myristate 13-acetate (PMA) and ionomycin (Fig. S5). The gene discussed is TAT; the disease is infection.