SIRT1 and diabetic kidney disease: The protective effect of H2S against diabetic nephropathy may be associated with a reduction in oxidative stress through enhanced antioxidant activity.329 SIRT1 is considered an anti-aging molecule that utilizes the coenzyme NAD+ to deacetylate target proteins, thereby exerting protective effects in the kidneys by inhibiting renal cell apoptosis,330 inflammation331 and fibrosis,332 ultimately slowing the progression of DKD.