In a mouse model of PD caused by the neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP),285 inhalation of H2S can prevent MPTP-induced motor impairments and the degeneration and apoptosis of tyrosine hydroxylase (TH)-containing neurons. The gene discussed is TH; the disease is Parkinson disease.