This process can also occur in the opposite direction, known as mesenchymal-epithelial transition (MET).378,379 Research has found that,380 H2S promoted EMT in human colon cancer HCT116 cells, and inhibiting H2S could significantly downregulate Wnt3 mRNA levels and β-catenin protein expression, as well as reduce ATP-citrate lyase (ACLY) mRNA and protein levels. This evidence concerns the gene ACLY and malignant colon neoplasm.