This suggests that the genetic features associated with disulfidptosis have various impacts on the occurrence, proliferation, and metastasis of lung cancer, and may provide insights for identifying patient prognosis.389 Furthermore, the levels of SAM are elevated in patients with NSCLC, suggesting its potential as a biomarker for early-stage NSCLC.390 Moreover, compared to normal pulmonary epithelial cells, NSCLC cells express higher levels of CBS, CSE and 3-MST, leading to increased production of H2S. H2S can induce migration and invasion of NSCLC cells, as well as the EMT process. Here, CBS is linked to non-small cell lung carcinoma.