MAPT and Alzheimer disease: AD is characterized by the aggregation of microtubule-associated protein Tau and Aβ peptide, forming neurofibrillary tangles and amyloid plaques, respectively.273–275 Hyperphosphorylation of Tau protein, a hallmark of AD, reduces its affinity for microtubules and causes it to aggregate.276,277 In AD mouse models, H2S donors can alleviate disease symptoms, improve spatial and cognitive deficits in mice.