Yan et al. revealedN-cadherin expression had a significantly opposite overall survivaland disease-free survival rate, which serves as a novel prognosticpredictor for CRC. In addition, the cadherinswitch from E to N, represented as the E-cadherin-to-N-cadherin ratio,mediated cancer progression via TGF-β-induced epithelial-to-mesenchymaltransition., This evidence concerns the gene CDH2 and cancer.