Additionally,the upregulated high mobility group box 1 (HMGB1) and γH2AXin tumors receiving combination therapy confirmed radiation-induceddamage (Figure B).However, the surviving tumor cells exhibited upregulation of the transcriptionfactor Snail, accompanied by persistent elevation of N-cadherin, MMP9,and vimentin. The gene discussed is HMGB1; the disease is neoplasm.