Remarkably, the tumours of the other three children (PD49348, PD54846, and PD63760), all of whom presented with Wilms tumours in the first few months of life, bore a single discernible driver mutation: a rearrangement of FOXR2. FOXR2 is an emerging oncogene in certain childhood cancers26–28 but has not previously been implicated in Wilms tumour. This evidence concerns the gene FOXR2 and neoplasm.