In line with enrichment analysis, 2 of these key genes, COL1A1 and COL1A2, are vital members of the collagen family, which is a crucial structural component of the ECM.[32] Giampieri et al[33] reported that COL1A1 can serve as a CSC differentiation marker, helping to predict relapse in resected CRC. Here, COL1A2 is linked to colorectal carcinoma.