The latest criteria for the diagnosis of GPA are based mainly on the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis.[12] According to the clinical criteria, patients with PR3-ANCA (or C-ANCA) positivity had the highest score of 5, and nasal involvement was followed by 3. This evidence concerns the gene PRTN3 and granulomatosis with polyangiitis.