CLOCK and Menkes disease: CRY1 is a key clock gene regulating circadian rhythms and biological clocks.[27,28] Research has shown that CRY1 interacts with mitochondrial proteins, influencing mitochondrial function and energy metabolism.[29] Its downregulation suggested it may participate in the occurrence and development of AS.[30] Studies have revealed that the deficiency of CRY1 can lead to MD, increased oxidative stress, and accelerated cellular aging, all of which are linked to AS.[31,32]