NR3C2 and Renal pseudohypoaldosteronism type 1: The NR3C2 gene, which encodes the mineralocorticoid receptor (MR), harbors over 380 rare coding variants that significantly influence mineralocorticoid homeostasis and disease susceptibility.[1] These variants include loss-of-function mutations linked to renal pseudohypoaldosteronism type 1 and gain-of-function mutations associated with inherited mineralocorticoid hypertension, which is typically characterized by low levels of renin and aldosterone.