Clinically, CD20 positivity reflects B cell infiltration and the secretion of IL-10 by tumor-associated macrophages (TAMs) with M2 polarization, which significantly contributes to an immunosuppressive microenvironment.[19] CD4 enhances antigen recognition and response by regulatory T cells through binding to major histocompatibility complex class II molecules. This evidence concerns the gene CD4 and neoplasm.