Specifically, the preliminary results of IVW revealed 3 inflammatory cytokines with positive causal effects on GERD, including C-X-C motif chemokine 1 [CXCL1, OR = 1.052, 95% CI: 1.004–1.103, P = .035], interleukin-1-alpha [IL-1α, OR = 1.083, 95% CI: 1.018–1.152, P = .012], interleukin-4 [IL-4, OR = 1.081, 95% CI: 1.018–1.147, P = .011]. This evidence concerns the gene IL4 and gastroesophageal reflux disease.