and could be used as a functional food ingredient for controlling type 2 diabetes.[36] A study has shown that glyasperin F could regulate cell growth by inhibiting the activation of MMP1, thereby reducing tissue damage and cell death caused by excessive inflammatory responses.[37] Vestitol is a flavonoid compound and it has been proven to have significant anti-inflammatory effects.[38] Thus, SMYAD might exert pharmacological effects on DFU through the above active ingredients. The gene discussed is MMP1; the disease is type 2 diabetes mellitus.